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ProductsBack/LIGHT/TNFSF14 Trimer, Human (HEK293, His-Flag)

LIGHT/TNFSF14 Trimer, Human (HEK293, His-Flag)

HY-P78477
MedChem Express
Protein IDO43557
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    MedChem Express
  • Product Name
    LIGHT/TNFSF14 Trimer, Human (HEK293, His-Flag)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Protein IDO43557
  • Protein Name
    Tumor necrosis factor ligand superfamily member 14
  • Scientific Description
    LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNgamma, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTbetaR-NIK-p52 NF-kappaB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag) is the extracellular part (S89-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with N-terminal His- and Flag-tag.
  • UNSPSC
    12352202