Lipid N2-3L

MedChem Express

Lipid N2-3L

5

Research Use Only

Lipid N2-3L is an ionizable cationic lipid (p K a = 8.99) that can be used to generate supramolecular lipid nanoparticles ( SMLNPs ) for mRNA delivery. Lipid nanoparticles formed by encapsulating a luciferase reporter gene with Lipid N2-3L were detected to accumulate in the lymph nodes of mice, indicating that they can effectively enter the mouse immune system. Lipid nanoparticles formed by encapsulating ovalbumin mRNA and the TLR7/8 agonist Resiquimod (HY-13740) with Lipid N2-3L were able to reduce tumor volume and increase survival in the MC-38-OVA mouse colon cancer model. Lipid N2-3L can be used in the research of drug delivery for cancer-related therapies [1] .

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