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LOC14 [877963-94-5]

Research Use Only
HY-100432
MedChem Express
CAS Number877963-94-5
DownloadMSDS
Product group Chemicals
Estimated Purity98.0
Molecular Weight317.41
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Overview

  • Supplier
    MedChem Express
  • Product Name
    LOC14 [877963-94-5]
  • Delivery Days Customer
    10
  • CAS Number
    877963-94-5
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Molecular Formula
    C16H19N3O2S
  • Molecular Weight
    317.41
  • Scientific Description
    LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding[1]. LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells[3].
  • SMILES
    O=C(C(C=CC=C1)=C1S2)N2CN3CCN(C(C4CC4)=O)CC3
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200