LOC14

MedChem Express

LOC14 [877963-94-5]

10

877963-94-5

98.0

C16H19N3O2S

317.41

LOC14 is a potent Protein disulfide isomerase ( PDI ) inhibitor with EC 50 and K d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding [1] . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells [3] .

O=C(C(C=CC=C1)=C1S2)N2CN3CCN(C(C4CC4)=O)CC3

2°C to 8°C

12352200