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Lometrexol

M27736
AbMole BioScience
CAS Number106400-81-1
Product group Chemicals
Molecular Weight443.45
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Lometrexol
  • Delivery Days Customer
    9
  • CAS Number
    106400-81-1
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C21H25N5O6
  • Molecular Weight
    443.45
  • Scientific Description
    Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
  • UNSPSC
    12352200

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