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Lornoxicam-d4
T71212
Overview
- SupplierTargetMol Chemicals
- Product NameLornoxicam-d4
- Delivery Days Customer65
- CAS Number1216527-48-8
- Category SupplierChemical
- Chemical NameLornoxicam-d4
- Molecular FormulaC13H6ClD4N3O4S2
- Molecular Weight375.85
- Scientific DescriptionLornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1alfa from arachidonic acid in Mono-Mac-6 cells, which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 uM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.
- Shelf life instruction3 years
- SMILESOC=1C2=C(S(=O)(=O)N(C)C1C(NC3=C(C(=C(C(=N3)[2H])[2H])[2H])[2H])=O)C=C(Cl)S2
- Storage Instruction-20°
- UNSPSC12352200