LOXO 195

Biorbyt

LOXO 195 [2097002-61-2]

16

2097002-61-2

Research Use Only

C20H21FN6O

380.4187

LOXO-195 is a next-generation TRK kinase (TKI) inhibitor, with IC50s of 0.6+/-0.1 nM, < 2.5 nM for TRKA and TRKC respectively.

FC1C([H])=NC2C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])N([H])C(C3C([H])=NN4C([H])=C([H])C(=NC4=3)N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C=2C=1[H])=O

12352200