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ProductsBack/LPAR1 Recombinant Monoclonal Antibody
Western Blot Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate All lanes: EDG2 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 42, 42 kDa Observed band size: 42 kDa
Western Blot Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate All lanes: EDG2 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 42, 42 kDa Observed band size: 42 kDa
Western Blot Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate All lanes: EDG2 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 42, 42 kDa Observed band size: 42 kDa

LPAR1 Recombinant Monoclonal Antibody

CSB-RA922556A0HU
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetLPAR1
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Overview

  • Supplier
    Cusabio
  • Product Name
    LPAR1 Recombinant Monoclonal Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    4C3
  • Conjugate
    Unconjugated
  • Gene ID1902
  • Target name
    LPAR1
  • Target description
    lysophosphatidic acid receptor 1
  • Target synonyms
    EDG2; edg-2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; Gpcr26; LPA receptor 1; LPA1; LPA-1; lysophosphatidic acid receptor 1; lysophosphatidic acid receptor Edg-2; Mrec1.3; rec.1.3; ventricular zone gene 1; VZG1; vzg-1
  • Isotype
    IgG
  • Protein IDQ92633
  • Protein Name
    Lysophosphatidic acid receptor 1
  • Scientific Description
    Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203