LS-104
HY-118084
Molecular Weight320.34
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameLS-104
- Delivery Days Customer9
- Molecular FormulaC19H16N2O3
- Molecular Weight320.34
- Scientific DescriptionLS-104 (Tyrene CR-4) is a non-ATP-competitive kinase inhibitor against JAK2 , Bcr-Abl and FLT3 . LS-104 potently induces apoptosis in JAK2V617F-positive cells and inhibits JAK2 autophosphorylation and downstream signal transduction. LS-104 also inhibits proliferation and induces potent cytotoxic effects in FLT3 expressing leukemic cells. LS-104 is a hydroxystyryl-acrylonitrile compound, which is promising for research of myeloproliferative disorders and refractory/relapsed hematologic malignancies [1] [2] .
- SMILESOC1=C(O)C=CC(/C=C/C=C(C#N)/C(NCC2=CC=CC=C2)=O)=C1
- UNSPSC12352200