LS-106

MedChem Express

LS-106

9

C24H28BrClN5OP

548.84

LS-106 is an orally active and potent inhibitor against epidermal growth factor receptor ( EGFR ) . LS-106 exhibits antitumor activities both in vitro and in vivo. LS-106 inhibits the kinase activities of EGFR 19del/T790M/C797S and EGFR L858R/T790M/C797S with IC 50 values of 2.4 nmol/L and 3.1 nmol/L, respectively, which is more potent than Osimertinib (HY-15772). LS-106 induces Apoptosis , suppresses cell proliferation of tumor cells harboring EGFR 19del/T790M/C797S and leas to significant tumor regression in a C797S-mutant xenograft model [1] .

CP(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(C)CC4)C(Br)=C3)=NC=C2Cl)(C)=O

12352200