Western blot analysis of extracts of human spleen cell lines, using LTA antibody.
Western blot analysis of extracts of human spleen cell lines, using LTA antibody.
LTA Antibody
CSB-PA013218KA01HU
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetLTA
Overview
- SupplierCusabio
- Product NameLTA Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4049
- Target nameLTA
- Target descriptionlymphotoxin alpha
- Target synonymsLT; LT-alpha; lymphotoxin-alpha; TNF superfamily, member 1; TNFB; TNF-beta; TNFSF1; TNLG1E; truncated lymphotoxin alpha; tumor necrosis factor beta; tumor necrosis factor ligand 1E; tumor necrosis factor ligand superfamily member 1
- HostRabbit
- IsotypeIgG
- Protein IDP01374
- Protein NameLymphotoxin-alpha
- Scientific DescriptionLymphotoxin-alpha (LT-alpha), also known as TNF-beta, is a member of the TNF superfamily of proteins. NK cells, T cells, B cells, and lymphoid tissue-inducer cells express LT-alpha. LT-alpha can be secreted as a soluble homotrimer or form membrane bound heterotrimers with lymphotoxin-beta (LT alpha1beta2 or LT alpha2beta1) which can be cleaved from the cell surface by matrix metalloproteases. Soluble LT-alpha binds to and signals through TNFR1/TNFR2, activating the canonical NF-kappaB pathway. In contrast, LT alpha1beta2 heterodimers bind to the LTbetaR receptor and activate the noncanonical NF-kappaB pathway. As a result, LT-alpha and TNF-alpha have overlapping functions. Soluble LT-alpha and LT alpha1beta2 play key roles in lymphangiogenesis. The LT alpha1beta2/LTbetaR axis is essential for the development of lymphoid tissue.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203