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LV-320
T11896
CAS Number2449093-46-1
Product group Chemicals
Molecular Weight520.11
Overview
- SupplierTargetMol Chemicals
- Product NameLV-320
- Delivery Days Customer10
- CAS Number2449093-46-1
- Category SupplierChemical
- Chemical NameLV-320
- Molecular FormulaC29H26ClNO2S2
- Molecular Weight520.11
- Scientific DescriptionLV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 uM and a K d of 16 uM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts [1].
- Shelf life instruction3 years
- SMILESC(=CC1=CC=C(C(SCCC2=CC=CC=C2)SCCC(O)=O)C=C1)C=3C4=C(N=CC3)C=C(Cl)C=C4
- Storage Instruction-20°
- UNSPSC12352200
References
- Bosc D, et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018 Aug 3;8(1):11653. doi: 10.1038/s41598-018-29900-x.Read more