LXQ46 [2097148-94-0]

TargetMol Chemicals

LXQ46 [2097148-94-0]

9

Research Use Only

C23H17Br2NO5

547.19

LXQ46 is an orally effective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 0.190 microM. It enhances insulin and leptin signaling pathways in insulin-resistant C2C12 cells. Additionally, LXQ46 improves type 2 diabetes and increases insulin tolerance in mouse models.

BrC=1C(Br)=C(C=C(O)C1O)C2=NC=C(O2)C=3C=CC(OC4=CC=C(OCC)C=C4)=CC3

-20°C

12352200