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ProductsBack/LY2784544 --- JAK2 inhibitor

LY2784544 --- JAK2 inhibitor

BS-60079C
Bioss Antibodies
Estimated Purity98.0
Product group Chemicals
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Overview

  • Supplier
    Bioss Antibodies
  • Product Name
    LY2784544 --- JAK2 inhibitor [1229236-86-5]
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Scientific Description
    LY2784544 is highly potent and selective mutant JAK2 (V617F) inhibitor with an IC50 of ~55 nM. It also inhibits IL-3-activated wild type JAK2 with an IC50 of 2.26 microM. Similarly in the proliferation assay, LY2784544 shows anti-proliferative activity in JAK2 V617F-driven cells with an IC50 of 68 nM, compared to 1.36 microM in wild type JAK2-driven cells and 0.94 microM in JAK3-driven cells. LY2784544 significantly inhibits STAT5 phosphorylation in JAK2-V617F Ba/F3 xenografts. Currently LY2784544 is being investigated in a clinical trial for the treatment of essential thrombocythemia, polycythemia vera, and primary myelofibrosis.
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000