LY411575 --- gamma-secretase Inhibitor

Bioss

LY411575 --- gamma-secretase Inhibitor [209984-57-6]

16

Research Use Only

98.0

LY411575 is a highly potent, selective, and orally bioavailable inhibitor of gamma secretase with an IC50 of ~0.1 nM for APP23 and APP51/16 in primary neurons. It has been shown to promote goblet cell differentiation in mouse intestine. LY411575 has also been observed to promote neural differentiation of mouse embryonic stem (ES) cells. In recent studies, LY411575 increased hair cell number in organ of Corti explants. Systemic LY411575 administration increased hair cell number and promoted hearing recovery in a noise-damaged cochlea, but local LY411575 administration promoted hearing recovery through transdifferentiation of supporting cells into hair cells after noise-induced hearing loss in the mature cochlea.

-20°C

51202000