Chemical Structure
Macrosporin [22225-67-8]
AG-CN2-0497
Overview
- SupplierAdipoGen Life Sciences
- Product NameMacrosporin [22225-67-8]
- Delivery Days Customer10
- CAS Number22225-67-8
- CertificationResearch Use Only
- Estimated Purity>98%
- Molecular FormulaC16H12O5
- Molecular Weight284.3
- Scientific DescriptionAnthraquinone antibiotic. Moderate antibacterial agent. Photosensitizer (through ROS production) and leaf necrosis inducer. Antiproliferative. Moderate cytotoxic in selected cancer cells. Shown to inhibit several protein kinases, including Aurora B and FLT3 in low microM range. Mycotoxin. Useful as a reference in food analysis. - Chemical. CAS: 22225-67-8. Formula: C16H12O5. MW: 284.3. Isolated from Stemphylium sp. Anthraquinone antibiotic. Moderate antibacterial agent. Photosensitizer (through ROS production) and leaf necrosis inducer. Antiproliferative. Moderate cytotoxic in selected cancer cells. Shown to inhibit several protein kinases, including Aurora B and FLT3 in low microM range. Mycotoxin. Useful as a reference in food analysis.
- SMILESOC1=CC2=C(C(C(C=C(OC)C=C3O)=C3C2=O)=O)C=C1C
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Studies on the metabolic products of Macrosporium porri Elliott Part IV. Structure of Macrosporin (Group III): R. Suemitsu, et al.; Agr. Biol. Chem. 25, 100 (1961)
- Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling Cladosporium: U. Hoeller, et al.; J. Nat. Prod. 65, 876 (2002)
- Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium: A. Debbab, et al.; J. Nat. Prod. 72, 626 (2009)
- Protein kinase inhibitors and other cytotoxic metabolites from the fungal endophyte Stemphylium botryosum isolated from Chenopodium album: A.H. Aly, et al.; Mycosphere - J. Fungal Biol. 1, 153 (2010)
- The role of macrosporin in necrotic spots: A. Trigos, et al.; Phytochem. Lett. 4, 122 (2011)
- Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. Fungus: C.-J. Zheng, et al.; J. Nat. Prod. 75, 189 (2012)