MAD1 antibody
GTX109519
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetMAD1L1
Overview
- SupplierGeneTex
- Product NameMAD1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID8379
- Target nameMAD1L1
- Target descriptionmitotic arrest deficient 1 like 1
- Target synonymsMAD1, MVA7, PIG9, TP53I9, TXBP181, mitotic spindle assembly checkpoint protein MAD1, MAD1 mitotic arrest deficient like 1, MAD1-like protein 1, mitotic arrest deficient 1-like protein 1, mitotic checkpoint MAD1 protein homolog, mitotic-arrest deficient 1, yeast, homolog-like 1, tax-binding protein 181, tumor protein p53 inducible protein 9
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y6D9
- Protein NameMitotic spindle assembly checkpoint protein MAD1
- Scientific DescriptionMAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Chen C, Piano V, Alex A, et al. The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex. Nat Commun. 2023,14(1):1529. doi: 10.1038/s41467-023-37235-zRead this paper
- Yamada C, Morooka A, Miyazaki S, et al. TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells. iScience. 2022,25(2):103675. doi: 10.1016/j.isci.2021.103675Read this paper
- Herman JA, Miller MP, Biggins S. chTOG is a conserved mitotic error correction factor. Elife. 2020,9. doi: 10.7554/eLife.61773Read this paper
- Shirnekhi HK, Herman JA, Paddison PJ, et al. BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis. J Biol Chem. 2020,295(43):14666-14677. doi: 10.1074/jbc.RA120.013598Read this paper
- Tzeng YW, Li DY, Chen Y, et al. LMO7 exerts an effect on mitosis progression and the spindle assembly checkpoint. Int J Biochem Cell Biol. 2018,94:22-30. doi: 10.1016/j.biocel.2017.11.006Read this paper
- Shirnekhi HK, Kelley EP, DeLuca JG, et al. Spindle assembly checkpoint signaling and sister chromatid cohesion are disrupted by HPV E6-mediated transformation. Mol Biol Cell. 2017,28(15):2035-2041. doi: 10.1091/mbc.E16-12-0853Read this paper
- Zhou H, Wang T, Zheng T, et al. Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nat Commun. 2016,7:10151. doi: 10.1038/ncomms10151Read this paper
- Tauchman EC, Boehm FJ, DeLuca JG. Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells. Nat Commun. 2015,6:10036. doi: 10.1038/ncomms10036Read this paper
- Caldas GV, Lynch TR, Anderson R, et al. The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells. Open Biol. 2015,5(11). doi: 10.1098/rsob.150160Read this paper
- Akera T, Goto Y, Sato M, et al. Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore. Nat Cell Biol. 2015,17(9):1124-33. doi: 10.1038/ncb3219Read this paper
Datasheet
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