MAD1 antibody
GTX109519
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mammals, Mouse, Rat
TargetMAD1L1
Overview
- SupplierGeneTex
- Product NameMAD1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID8379
- Target nameMAD1L1
- Target descriptionmitotic arrest deficient 1 like 1
- Target synonymsMAD1; MAD1 mitotic arrest deficient like 1; MAD1-like protein 1; mitotic arrest deficient 1-like protein 1; mitotic checkpoint MAD1 protein homolog; mitotic spindle assembly checkpoint protein MAD1; mitotic-arrest deficient 1, yeast, homolog-like 1; PIG9; tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y6D9
- Protein NameMitotic spindle assembly checkpoint protein MAD1
- Scientific DescriptionMAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
- ReactivityHuman, Mammals, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex.Read more
- TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells. Yamada C et al., 2022 Feb 18, iScienceRead more
- chTOG is a conserved mitotic error correction factor. Herman JA et al., 2020 Dec 30, ElifeRead more
- BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis. Shirnekhi HK et al., 2020 Oct 23, J Biol ChemRead more
- LMO7 exerts an effect on mitosis progression and the spindle assembly checkpoint. Tzeng YW et al., 2018 Jan, Int J Biochem Cell BiolRead more
- Spindle assembly checkpoint signaling and sister chromatid cohesion are disrupted by HPV E6-mediated transformation. Shirnekhi HK et al., 2017 Jul 15, Mol Biol CellRead more
- Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Zhou H et al., 2016 Jan 8, Nat CommunRead more
- Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells. Tauchman EC et al., 2015 Dec 1, Nat CommunRead more
- The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells. Caldas GV et al., 2015 Nov, Open BiolRead more
- Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore. Akera T et al., 2015 Sep, Nat Cell BiolRead more