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Western blot analysis of extracts from HuvEc cells, HepG2 cells, HeLa cells and COLO205 cells, using Maf antibody.
Western blot analysis of extracts from HuvEc cells, HepG2 cells, HeLa cells and COLO205 cells, using Maf antibody.
Western blot analysis of extracts from HuvEc cells, HepG2 cells, HeLa cells and COLO205 cells, using Maf antibody.

MAF Antibody

Research Use Only
CSB-PA796747
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetMAF
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Overview

  • Supplier
    Cusabio
  • Product Name
    MAF Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID4094
  • Target name
    MAF
  • Target description
    MAF bZIP transcription factor
  • Target synonyms
    Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; AYGRP; CCA4; c-MAF; c-maf proto-oncogene; CTRCT21; proto-oncogene c-Maf; T lymphocyte c-maf long form; transcription factor Maf; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO75444
  • Protein Name
    Transcription factor Maf
  • Scientific Description
    Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5-[GT]G[GC]N[GT]NCTCAGNN-3 in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells By similarity. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Chesi M., Blood 91:4457-4463(1998). Jamieson R.V., Hum. Mol. Genet. 11:33-42(2002). Vanita V., Am. J. Med. Genet. A 140:558-566(2006).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203