Mafosfamide [88859-04-5]

TargetMol Chemicals

Mafosfamide [88859-04-5]

72

Chemical

Mafosfamide

C9H19Cl2N2O5PS2

401.27

Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis.

3 years

N(CCCl)(CCCl)P1(=O)N[C@H](SCCS(=O)(=O)O)CCO1

-20°C

12352200