MAGI3 antibody

GeneTex

MAGI3 antibody

9

Staining by immunoblotting and immunofluorescence is specifically inhibited by the immunizing peptide.

WB: 1.0 microg/ml. ICC/IF: 2.0 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

Magi3

membrane associated guanylate kinase, WW and PDZ domain containing 3

MAGI-3; membrane-associated guanylate kinase inverted 3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; membrane-associated guanylate kinase-related (MAGI-3); scaffolding protein SLIPR; scaffolding-like protein; Slipr

Rabbit

IgG

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

MAGI3 (membrane-associated guanylate cyclase of inverted orientation-3) is a member of the family of membrane-associated guanylate kinases (MAGUKs) that comprise peripheral membrane proteins involved in the formation of specialized cell-cell junctions. MAGI3, as well as other proteins in this family are characterized by three types of protein-protein interaction modules: five PDZ domains, an N-terminal guanylate kinase (GK) domain, and a WW domain. The WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, mediates protein-protein interactions through binding to short proline-rich sequences). MAGI3 and PTEN/MMAC together modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions PTEN/MMAC phosphatase to specific subcellular locations that are involved in the regulation of cell proliferation and survival.

Rat

-20°C or -80°C,2°C to 8°C

12352203