Major Vault Protein (MVP)(1014), CF640R conjugate, 0.1mg/mL [26628-22-8]

Biotium

Major Vault Protein (MVP)(1014), CF640R conjugate, 0.1mg/mL

9

ImmunoFluorescence, Western Blot

Research Use Only

Monoclonal

1014

0.1 mg/ml

Other Conjugate

MVP

major vault protein

LRP; lung resistance-related protein; major vault protein; testicular secretory protein Li 30; VAULT1

Mouse

IgG1

Major vault protein

Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203