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Chemical Structure
Chemical Structure
Chemical Structure

Malformin C [59926-78-2]

Research Use Only
AG-CN2-0107
AdipoGen Life Sciences
CAS Number59926-78-2
Product group Chemicals
Estimated Purity>95% (HPLC)
Molecular Weight529.7
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Malformin C [59926-78-2]
  • Delivery Days Customer
    10
  • CAS Number
    59926-78-2
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (HPLC)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C23H39N5O5S2
  • Molecular Weight
    529.7
  • Scientific Description
    Chemical. CAS: 59926-78-2. Formula: C23H39N5O5S2. MW: 529.7. Synthetic. Originally isolated from Aspergillus niger FKI-2342. Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents. - Peptide antibiotic [1]. Induces root curvature and malformation in plants [1]. Antibacterial [1, 2], antimalarial and antitrypanosomal [4]. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents [3].
  • SMILES
    CC(C)C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]2CSSC[C@@H](NC1=O)C(=O)N2)C(C)C
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Malformin C, a new metabolite of Aspergillus niger: R.J. Anderegg, et al.; JACS 98, 3365 (1976)
  • Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger: B. Kobbe, et al.; Appl. Environ. Microbiol. 33, 996 (1977)
  • Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells: K. Hagimori, et al.; Biol. Pharm. Bull. 30, 1379 (2007)
  • Solid-phase synthesis and biological activity of malformin C and its derivatives: Y. Kojima, et al.; J. Antibiot. (Tokyo) 62, 681 (2009)