Bio-Connect

MAML2 (Mastermind Like Transcriptional Coactivator 2) (MAML2/1302), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC041302
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetMAML2
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Overview

  • Supplier
    Biotium
  • Product Name
    MAML2 (Mastermind Like Transcriptional Coactivator 2) (MAML2/1302), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    MAML2/1302
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID84441
  • Target name
    MAML2
  • Target description
    mastermind like transcriptional coactivator 2
  • Target synonyms
    MAM2; mam-2; MAM3; MAM-3; mastermind-like 2; mastermind-like protein 2; MLL-MAML2
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203