MAML3 (Mastermind Like Transcriptional Coactivator 3) (MAML3/1303), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC041303
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetMAML3
Overview
- SupplierBiotium
- Product NameMAML3 (Mastermind Like Transcriptional Coactivator 3) (MAML3/1303), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMAML3/1303
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID55534
- Target nameMAML3
- Target descriptionmastermind like transcriptional coactivator 3
- Target synonymsCAG repeat containing (glia-derived nexin I alpha); CAGH3; ERDA3; expanded repeat domain, CAG/CTG 3; GDN; MAM2; MAM-2; mam-3; mastermind-like protein 3; polyglutamine rich; TNRC3; trinucleotide repeat containing 3
- HostMouse
- IsotypeIgG1
- Scientific DescriptionMAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203