Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MANF Polyclonal Antibody at dilution 1:70
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MANF Polyclonal Antibody at dilution 1:70
MANF Polyclonal Antibody
E-AB-12987
Product group Antibodies
Overview
- SupplierElabscience
- Product NameMANF Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.1mg/ml
- Scientific DescriptionThe protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
- UNSPSC12352203