MAO A/HSP90-IN-1 [2927489-95-8]

MedChem Express

MAO A/HSP90-IN-1 [2927489-95-8]

14

2927489-95-8

Research Use Only

C24H29ClN2O4

444.95

MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 microM and 0.019 microM in Glioblastoma (GBM) GL26 cells and HSP90alpha, respectively. MAO A/HSP90-IN-1 (4-b) can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 (4-b) have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 (4-b) can be used for brain tumor-related diseases research[1].

CN(C1=CC(Cl)=C(C=C1)OCCCN(CC#C)C)C(C2=C(C=C(C(C(C)C)=C2)O)O)=O

12352200