Western Blot analysis of Hela, NIH/3T3 and Jurkat cell using MAP2K2 Polyclonal Antibody at dilution of 1:1900
Western Blot analysis of Hela, NIH/3T3 and Jurkat cell using MAP2K2 Polyclonal Antibody at dilution of 1:1900
MAP2K2 Polyclonal Antibody
E-AB-12553
Product group Antibodies
Overview
- SupplierElabscience
- Product NameMAP2K2 Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA WB IHC
- CertificationResearch Use Only
- Concentration1mg/ml
- Scientific DescriptionThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
- UNSPSC12352203