MAPKBP1 antibody

GeneTex

MAPKBP1 antibody

9

WB: 1:500 - 1:2000. IHC-P: 1:50 - 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

MAPKBP1

mitogen-activated protein kinase binding protein 1

JNK-binding protein 1; JNKBP1; JNKBP-1; mitogen-activated protein kinase-binding protein 1; NPHP20

Rabbit

IgG

Mitogen-activated protein kinase-binding protein 1

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203