Western blot analysis of extracts of various cell lines using MAPKBP1 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using MAPKBP1 Polyclonal Antibody at 1:1000 dilution.
MAPKBP1 Polyclonal Antibody
E-AB-63068
Product group Antibodies
Overview
- SupplierElabscience
- Product NameMAPKBP1 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
- UNSPSC12352203