MAPKBP1 Polyclonal Antibody

Reddot Biotech

MAPKBP1 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

MAPKBP1

mitogen-activated protein kinase binding protein 1

JNK-binding protein 1; JNKBP1; JNKBP-1; mitogen-activated protein kinase-binding protein 1; NPHP20

Rabbit

IgG

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.

Human, Mouse, Rat

-20°C

12352203