IHC-P analysis of formalin fixed human prostate cancer tissue section using GTX56127 MARCH-I antibody. Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)
IHC-P analysis of formalin fixed human prostate cancer tissue section using GTX56127 MARCH-I antibody. Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)
MARCH-I antibody
GTX56127
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetMARCHF1
Overview
- SupplierGeneTex
- Product NameMARCH-I antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500 - 1:1000. IHC-P: 1:100 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID55016
- Target nameMARCHF1
- Target descriptionmembrane associated ring-CH-type finger 1
- Target synonymsE3 ubiquitin-protein ligase MARCH1; E3 ubiquitin-protein ligase MARCHF1; MARCH1; MARCH-I; membrane associated ring finger 1; membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; membrane-associated RING finger protein 1; membrane-associated RING-CH protein I; RING finger protein 171; RING-type E3 ubiquitin transferase MARCH1; RING-type E3 ubiquitin transferase MARCHF1; RNF171
- HostRabbit
- IsotypeIgG
- Protein IDQ8TCQ1
- Protein NameE3 ubiquitin-protein ligase MARCH1
- Scientific DescriptionMARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203