Western blot analysis of extracts from HeLa cells, using MARK antibody.
Western blot analysis of extracts from HeLa cells, using MARK antibody.
MARK1 Antibody
CSB-PA219426
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMARK1
Overview
- SupplierCusabio
- Product NameMARK1 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4139
- Target nameMARK1
- Target descriptionmicrotubule affinity regulating kinase 1
- Target synonymsMAP/microtubule affinity-regulating kinase 1; MARK; PAR1 homolog c; Par1c; Par-1c; serine/threonine-protein kinase MARK1
- HostRabbit
- IsotypeIgG
- Protein IDQ9P0L2
- Protein NameSerine/threonine-protein kinase MARK1
- Scientific DescriptionSerine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Lizcano J.M., EMBO J. 23:833-843(2004). Nagase T., DNA Res. 7:143-150(2000). Gregory S.G., Nature 441:315-321(2006).
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC12352203