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MARK1 Polyclonal Antibody

RD79143A
Reddot Biotech
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetMARK1
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    MARK1 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4139
  • Target name
    MARK1
  • Target description
    microtubule affinity regulating kinase 1
  • Target synonyms
    MAP/microtubule affinity-regulating kinase 1; MARK; PAR1 homolog c; Par1c; Par-1c; serine/threonine-protein kinase MARK1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The microtubule matrix within a cell plays a central role in intracellular transport, cell shape during differentiation and chromosome partitioning during mitosis. During these processes, microtubules transition rapidly between stable and dynamic states. MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203