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Western blot analysis of extracts from COS-7 cells, using MARK2 antibody.
Western blot analysis of extracts from COS-7 cells, using MARK2 antibody.
Western blot analysis of extracts from COS-7 cells, using MARK2 antibody.

MARK2 Antibody

Research Use Only
CSB-PA211429
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetMARK2
Price on request
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More than 130 suppliers
ISO certified
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Overview

  • Supplier
    Cusabio
  • Product Name
    MARK2 Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID2011
  • Target name
    MARK2
  • Target description
    microtubule affinity regulating kinase 2
  • Target synonyms
    ELKL motif kinase 1; EMK1; EMK-1; MAP/microtubule affinity-regulating kinase 2; PAR-1; PAR1 homolog b; Par1b; Par-1b; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK; serine/threonine-protein kinase MARK2; testicular tissue protein Li 117
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ7KZI7
  • Protein Name
    Serine/threonine-protein kinase MARK2
  • Scientific Description
    Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Espinosa L., Cytogenet. Cell Genet. 81:278-282(1998). Lizcano J.M., EMBO J. 23:833-843(2004). Taylor T.D., Nature 440:497-500(2006).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203