MASP1 (cleaved Arg448) antibody

GeneTex

MASP1 (cleaved Arg448) antibody

9

MASP1 (cleaved Arg448) antibody detects endogenous levels of fragment of activated MASP1 resulting from cleavage adjacent to Arg448.

WB: 1:500~1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Liquid

MASP1

MBL associated serine protease 1

3MC1; C4/C2 activating component of Ra-reactive factor; complement factor MASP-3; complement-activating component of Ra-reactive factor; CRARF; CRARF1; mannan binding lectin serine peptidase 1; mannan-binding lectin serine protease 1; mannose-associated serine protease 1; mannose-binding lectin-associated serine protease 1; mannose-binding protein-associated serine protease; MAP1; MAP-1; MAp44; MASP; MASP3; MASP-3; PRSS5; Ra-reactive factor serine protease p100; RaRF; serine protease 5

Mannan-binding lectin serine protease 1

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

-20°C or -80°C,2°C to 8°C

12352203