![MBD1 (Methyl-CpG Binding Domain Protein 1)(CPTC-MBD1-1), CF405S conjugate, 0.1mg/mL [26628-22-8] MBD1 (Methyl-CpG Binding Domain Protein 1)(CPTC-MBD1-1), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2021/02/view_image-68.jpeg)
MBD1 (Methyl-CpG Binding Domain Protein 1)(CPTC-MBD1-1), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC042271
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetMBD1
Overview
- SupplierBiotium
- Product NameMBD1 (Methyl-CpG Binding Domain Protein 1)(CPTC-MBD1-1), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCPTC-MBD1-1
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID4152
- Target nameMBD1
- Target descriptionmethyl-CpG binding domain protein 1
- Target synonymsCXXC3; CXXC-type zinc finger protein 3; methyl-CpG-binding domain protein 1; PCM1; protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription
- HostMouse
- IsotypeIgG1
- Protein IDQ9UIS9
- Protein NameMethyl-CpG-binding domain protein 1
- Scientific DescriptionDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has also been predicted to be involved in the development and progression of tumors, and it has been shown that MBD1 is significantly upregulated in pancreatic cancer tissues when compared with surrounding normal tissues. Furthermore, MBD1 may serve as a potential therapeutic target for pancreatic cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203