MBM-55

MedChem Express

MBM-55 [2083622-09-5]

10

2083622-09-5

99.94

C28H27FN6O2

498.55

MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC 50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 ( IC 50 =5.4 nM) and DYRK1a ( IC 50 =6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis . MBM-55 shows antitumor activities, and no obvious toxicity to mice [1] .

NC(C(C=C1)=C(OCC2=CC=CC(F)=C2)C=C1C3=CN=C4N3C=CC(C5=CN(CCN(C)C)N=C5)=C4)=O

2°C to 8°C

12352200