MBM-55S

MedChem Express

MBM-55S [2083624-07-9]

10

2083624-07-9

C36H39FN6O10

734.73

MBM-55S is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC 50 of 1 nM. MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 ( IC 50 =5.4 nM) and DYRK1a ( IC 50 =6.5 nM). MBM-55S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis . MBM-55S shows antitumor activities, and no obvious toxicity to mice [1] .

NC(C(C=C1)=C(OCC2=CC=CC(F)=C2)C=C1C3=CN=C4N3C=CC(C5=CN(CCN(C)C)N=C5)=C4)=O.O=C(O)CCC(O)=O.O=C(O)CCC(O)=O

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