Mca-SEVNLDAEFK(Dnp)
HY-P4919
Molecular Weight1533.50
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameMca-SEVNLDAEFK(Dnp)
- Delivery Days Customer14
- CertificationResearch Use Only
- Molecular FormulaC68H88N14O27
- Molecular Weight1533.50
- Scientific DescriptionMca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the Swedish Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) beta-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
- SMILESO=[N+]([O-])C(C=C(C=C1)[N+]([O-])=O)=C1NCCCC[C@@H](C(O)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O)=O)=O)=O)=O)=O)=O
- UNSPSC12352200