MCM3AP Antibody

Cusabio

MCM3AP Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

MCM3AP

minichromosome maintenance complex component 3 associated protein

80 kDa MCM3-associated protein; GANP; germinal center-associated nuclear protein; germinal-center associated nuclear protein; germinal-centre associated nuclear protein; MAP80; MCM3 acetylating protein; MCM3 acetyltransferase; MCM3 import protein; MCM3 minichromosome maintenance deficient 3 associated protein; PNRIID; SAC3

Rabbit

IgG

Germinal-center associated nuclear protein

Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation. Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494. Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328. Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834. Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.

Human

-20°C or -80°C

12352203