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MCM6 Antibody

Research Use Only
ORB639801
Biorbyt
ApplicationsImmunoHistoChemistry
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Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    Biorbyt
  • Product Name
    MCM6 Antibody
  • Delivery Days Customer
    16
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml IHC-P
  • Certification
    Research Use Only
  • Clone ID
    MCM6/2999
  • Isotype
    IgG
  • Scientific Description
    The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.
  • UNSPSC
    12352203