MDM2 Polyclonal Antibody

Reddot Biotech

MDM2 Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

MDM2

MDM2 proto-oncogene

ACTFS; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; hdm2; HDMX; LSKB; MDM2 oncogene, E3 ubiquitin protein ligase; MDM2 proto-oncogene, E3 ubiquitin protein ligase; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; oncoprotein Mdm2

Rabbit

IgG

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Human, Mouse, Rat

-20°C

12352203