Bio-Connect

MDM4 Polyclonal Antibody

RD267135A
Reddot Biotech
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetMDM4
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    MDM4 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4194
  • Target name
    MDM4
  • Target description
    MDM4 regulator of p53
  • Target synonyms
    BMFS6; double minute 4, human homolog of; p53-binding protein; HDMX; mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4, p53 regulator; MDM4-related protein 1; MDMX; MRP1; protein Mdm4; protein Mdmx
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latters degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203