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Chemical Structure
Chemical Structure
Chemical Structure

Me6BIO [667463-95-8]

Research Use Only
AG-MR-C0021
AdipoGen Life Sciences
CAS Number667463-95-8
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight370.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Me6BIO [667463-95-8]
  • Delivery Days Customer
    10
  • CAS Number
    667463-95-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C17H12BrN3O2
  • Molecular Weight
    370.2
  • Scientific Description
    Chemical. CAS: 667463-95-8. Formula: C17H12BrN3O2. MW: 370.2. N-methylated inactive control analog of 6-bromoindirubin-3-oxime (6BIO) (Prod. No. MR-C0019). Displays minimal activity against CDK1/Cyclin B, GSK-3 alpha/beta and CDK5/p25. Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus. - N-methylated inactive control analog of 6-bromoindirubin-3-oxime (6BIO) (Prod. No. MR-C0019). Displays minimal activity against CDK1/Cyclin B, GSK-3 alpha/beta and CDK5/p25. Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
  • SMILES
    CN1C(=O)\C(=C2/NC3=CC=CC=C3/C/2=N\O)C2=C1C=C(Br)C=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol. 10, 1255 (2003)
  • Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004)
  • Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins: M. Knockaert, et al.; Oncogene 23, 4400 (2004)
  • The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol. 13, 957 (2006)
  • Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In «Life in Progress», Station Biologique, Roscoff, 297 pp. (2006)
  • Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments: S.P. Williams, et al.; Cancer Res. 71, 5374 (2011)
  • Pleiotrophin suppression of receptor protein tyrosine phosphatase-beta/zeta maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells: C.R. McClain, et al.; J. Neurosci. 32, 15066 (2012)