MED13 antibody
GTX129674
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse
TargetMED13
Overview
- SupplierGeneTex
- Product NameMED13 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID9969
- Target nameMED13
- Target descriptionmediator complex subunit 13
- Target synonymsARC250, DRIP250, HSPC221, MRD61, THRAP1, TRAP240, mediator of RNA polymerase II transcription subunit 13, activator-recruited cofactor 250 kDa component, mediator of RNA polymerase II transcription, subunit 13 homolog, thyroid hormone receptor-associated protein 1, thyroid hormone receptor-associated protein complex 240 kDa component, thyroid hormone receptor-associated protein complex component TRAP240, thyroid hormone receptor-associated protein, 240 kDa subunit, vitamin D3 receptor-interacting protein complex component DRIP250
- HostRabbit
- IsotypeIgG
- Protein IDQ9UHV7
- Protein NameMediator of RNA polymerase II transcription subunit 13
- Scientific DescriptionThis gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Dimitrova E, Feldmann A, van der Weide RH, et al. Distinct roles for CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction. Nat Struct Mol Biol. 2022,29(10):1000-1010. doi: 10.1038/s41594-022-00840-5Read this paper
- Feldmann A, Dimitrova E, Kenney A, et al. CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions. Nucleic Acids Res. 2020,48(6):2942-2955. doi: 10.1093/nar/gkaa064Read this paper
- Dimitrova E, Kondo T, Feldmann A, et al. FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment. Elife. 2018,7. doi: 10.7554/eLife.37084Read this paper




