Bio-Connect

MED13 antibody

GTX129674
GeneTex
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse
TargetMED13
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Overview

  • Supplier
    GeneTex
  • Product Name
    MED13 antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID:36220895)
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9969
  • Target name
    MED13
  • Target description
    mediator complex subunit 13
  • Target synonyms
    activator-recruited cofactor 250 kDa component; ARC250; DRIP250; HSPC221; mediator of RNA polymerase II transcription subunit 13; mediator of RNA polymerase II transcription, subunit 13 homolog; MRD61; THRAP1; thyroid hormone receptor-associated protein 1; thyroid hormone receptor-associated protein complex 240 kDa component; thyroid hormone receptor-associated protein complex component TRAP240; thyroid hormone receptor-associated protein, 240 kDa subunit; TRAP240; vitamin D3 receptor-interacting protein complex component DRIP250
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9UHV7
  • Protein Name
    Mediator of RNA polymerase II transcription subunit 13
  • Scientific Description
    This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Distinct roles for CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction.
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  • CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions. Feldmann A et al., 2020 Apr 6, Nucleic Acids Res
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  • FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment. Dimitrova E et al., 2018 May 29, Elife
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