MEF2C Antibody

Cusabio

MEF2C Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

MEF2C

myocyte enhancer factor 2C

C5DELq14.3; DEL5q14.3; MADS box transcription enhancer factor 2, polypeptide C; myocyte-specific enhancer factor 2C; NEDHSIL

Rabbit

IgG

Myocyte-specific enhancer factor 2C

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture By similarity. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993). McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993). Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).

Human, Mouse

-20°C or -80°C

12352203