Melicopine

MedChem Express

Melicopine [568-01-4]

5

Research Use Only

Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum , with IC 50 values of 29.7 and 33.7 microg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP ( IC 50 values of 47.9 and 37.8 microg/mL), but has no effect on non-cancerous HEK293 cells ( IC 50 greater than 100 microg/mL). Melicopine holds promise for research in anticancer and anti-infection fields [1] .

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