Bio-Connect

MELK-8a

HY-100368
MedChem Express
CAS Number1922153-17-0
Product group Chemicals
Estimated Purity98.32
Molecular Weight432.56
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MELK-8a [1922153-17-0]
  • Delivery Days Customer
    10
  • CAS Number
    1922153-17-0
  • Estimated Purity
    98.32
  • Molecular Formula
    C25H32N6O
  • Molecular Weight
    432.56
  • Scientific Description
    MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase ( MELK ) inhibitor with IC 50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRalpha with IC 50 s of 0.18, 0.19, and 0.42 microM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells [1] .
  • SMILES
    CN(CC1)CCN1C2=CC=C(N3C=C(C4=CC=NC=C4OCC5CCNCC5)C=N3)C=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200