Melperone

MedChem Express

Melperone [3575-80-2]

10

3575-80-2

Research Use Only

99.84

C16H22FNO

263.35

Melperone is a butyrophenone with atypical antipsychotic properties. Melperone is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, alpha1-adrenergic, and alpha2-adrenergic receptors, respectively. Melperone has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone is also a CYP2D6 inhibitor. Melperone can be used for the study of schizophrenia, and agitation in the elderly[1][2][3][4].

O=C(C1=CC=C(F)C=C1)CCCN2CCC(C)CC2

-20°C,2°C to 8°C

12352200