Mepazine hydrochloride

Selleck Chemicals

Mepazine hydrochloride [2975-36-2]

9

Research Use Only

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Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of MALT1 protease, with IC50 values of 0.83 microM for GSTMALT1 full length and 0.42 microM for GSTMALT1 aa 325-760. It effectively suppresses the activation of the NF-kB pathway specifically in activated B cell subtype of diffuse large B cell lymphoma (ABC-DLBCL) cells and makes it a promising candidate for the treatment of ABC-DLBCL.

51202000