CgoaEGY7KcaEc23qAAAAAHiOy2E081.png
CgoaEGY7KcaEc23qAAAAAHiOy2E081.png
Merestinib dihydrochloride
T15808
CAS Number1206801-37-7
Product group Chemicals
Molecular Weight625.45
Overview
- SupplierTargetMol Chemicals
- Product NameMerestinib dihydrochloride
- Delivery Days Customer14
- CAS Number1206801-37-7
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameMerestinib dihydrochloride
- Molecular FormulaC30H24Cl2F2N6O3
- Molecular Weight625.45
- Scientific DescriptionMerestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).
- Shelf life instruction3 years
- SMILESO=C(C1=CC=C(C)N(C2=CC=C(C=C2)F)C1=O)NC3=CC=C(C(F)=C3)OC4=CC5=C(C=C4C6=CNN=C6)N(C)N=C5.Cl.Cl
- Storage Instruction-20°
- UNSPSC12352200
References
- Yan SB, et al. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. Invest New Drugs. 2013 Aug;31(4):833-44.Read more